MOTS-c 10mg
€40,00
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MOTS-c 10mg
€40,00
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA type-c) is a unique mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome. It acts as a major regulator of cellular energy balance and metabolic homeostasis, often researched as an "exercise mimetic" due to its ability to simulate the metabolic benefits of physical activity.
Research Relevance: Extensively studied in metabolic health, longevity, muscle metabolism, and insulin sensitivity. Under stress, MOTS-c translocates to the cell nucleus to modulate nuclear gene expression in response to metabolic demands.
Specifications
| Name | MOTS-c |
| Type | Research Peptide: Mitochondrial-Derived Peptide (MDP) |
| Amino Acid Count | 16 |
| Purity | ± 99% (HPLC – COA available) |
| Molecular Weight | 2174.62 g/mol |
| Analysis | HPLC, MS |
| Form | Lyophilized powder |
Confidential Lab Data - Specification Sheet
Molecular Formula
C101H152N28O22S2
Amino Acid Sequence (MOTS-c)
1Met
2Arg
3Trp
4Gln
5Glu
6Met
7Gly
8Tyr
9Ile
10Phe
11Tyr
12Pro
13Arg
14Lys
15Leu
16Arg
MOTS-c: The Mitochondrial Metabolic Regulator
Discovered in 2015, MOTS-c represents a breakthrough in mitochondrial biology. Unlike most peptides encoded in nuclear DNA, MOTS-c originates within the mitochondrial 12S rRNA gene, playing a crucial role in cellular energy regulation and inter-organelle communication.
Primary Research Focus Areas
- AMPK Pathway Activation: MOTS-c targets the folate cycle to activate AMPK (AMP-activated protein kinase), the cell's master metabolic sensor, promoting glucose uptake and fatty acid oxidation.
- Exercise Mimetic Properties: Studies suggest MOTS-c increases capacity for physical endurance and muscle insulin sensitivity, mimicking several cellular physiological changes induced by exercise.
- Metabolic Stress & Longevity: Under metabolic stress, MOTS-c translocates directly to the nucleus to regulate gene expression for adaptive stress responses and cellular longevity.